Role of Chlorhexidine in its Different Formats for the Prevention of Dry Socket: Scoping Review

2024 • Volume 18 • Issue 1

Ignacio Olivares-Unamuno; Constanza Donoso-Alviña; Francisca Alcázar-Carrasco; Ignacio Sanino-Zavala & Rodrigo Quitral-Argandoña



The objective of this study was to investigate the role of chlorhexidine in its different formats in the prevention of dry socket after dental extraction. The electronic search was performed using keywords and MeSH terms in the databases of PubMed, Scopus, Web of Science, until 2021. The reviewers independently performed the analysis of the articles. The initial search resulted in 192 articles. 59 duplicate articles were discarded, and an initial general review of titles and abstracts was performed, verifying that the pre-established inclusion and exclusion criteria were met. Of 192 studies, 25 met the inclusion criteria. Of the 25 articles, 10 included patients with risk factors associated with dry socket. Regarding the site of dental extraction, 19 articles included patients with mandibular third molars. Within the filtered articles, three formats of chlorhexidine were used: rinse, bioadhesive gel and irrigant, in different concentrations, and compared with different placebo groups. Of the included studies, 18 reported that chlorhexidine in its different formats provided a decrease in the incidence of dry socket versus the control group. The use of chlorhexidine in its different formats after dental extraction, is highly effective in preventing dry socket. However, we infer that new research lines are needed that include patients with associated risk factors, and studies that do not use complementary therapies.

KEY WORDS: socket, alveolar osteitis; chlorhexidine gluconate: prevention of alveolar osteitis: intra-alveolar medication.


How to cite this article

OLIVARES-UNAMUNO, I.; DONOSO-ALVIÑA, C.; ALCÁZAR-CARRASCO, F.; SANINO-ZAVALA, I.; QUITRAL-ARGANDOÑA, R. Role of chlorhexidine in its different formats for the prevention of dry socket: Scoping Review. Int. J. Odontostomat., 18(1):12-18, 2024.


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