Myoepithelial carcinoma is a rare malignant neoplasm of the salivary glands; it may originate de novo or develop into a pre-existing pleomorphic adenoma or myoepithelioma. The histological and immunohistochemical characteristics of a case of myoepithelial carcinoma of the parotid gland originated by the malignant transformation of a previous primary pleomorphic adenoma were investigated in this work. The presence of mitosis, nuclear pleomorphism, necrotic areas, myoepitheliocytes with a p63 labeling greater than 75 % and a proliferative index of 15 % were demonstrated, characteristics that can trigger an adverse outcome. The periodic examination of the patient is essential, which will give a higher probability of cure and survival and to investigate eventual recurrences or metastases.
KEY WORDS: salivary tumors, carcinoma expleomorphic adenoma, myoepithelial carcinoma, immunohistochemistry.
How to cite this article
SAMAR, R. M. E.; AVILA, U. R. E.; CORBALL DE SANTIAGO, A. G.; FONSECA, A. I. B. & FERNÁNDEZ, C. J. E. Myoepithelial carcinoma ex-pleomorphic adenoma of parotid gland: A case report and immunohistochemical analysis. Int. J. Odontostomat., 16(3):377-383, 2022.