Comparative Study of Postoperative Anti-inflammatory Effectiveness when Using intravenous Dexamethasone Versus Intravenous Ketoprofen Prior to Extraction of Mandibular third Molars Included

2021 • Volume 15 • Issue 4

Cristhian Collazos Peña; Diego Fonseca Escobar; Fernando Parada Fernández & Sandra Montero Riffo



The extraction of included third molars most of the time involves an acute inflammatory picture, postoperative pain and trismus. At present, various pharmacological protocols have been proposed in order to prevent these complications, where the most widely used are analgesics and corticosteroids. Compare Dexamethasone and Ketoprofen used intravenously prior to surgery of mandibular third molars included, in the control of edema, pain and trismus. An experimental, analytical, cross-sectional study was carried out, authorized by the ethics committee of the Andrés Bello University. Thirty subjects who required extraction of included mandibular third molars were chosen, 15randomly received intravenous Dexamethasone 4 mg and 15 intravenous Ketoprofen 200 mg 30 minutes before the intervention. The surgical procedure was standardized, facial edema, trismus and postoperative pain were evaluated at 2 and 7 days after the surgery. There was a statistically significant difference only in 2 facial measures, of the 5 taken, when comparing the percentage of edema at 7 postoperative days between both experimental groups. Most of the Dexamethasone group had a larger volume edema compared to the Ketoprofen group. In relation to pain and trismus, significant differences were only observed in the intensity of pain evaluated at 7 days, being greater in the Ketoprofen group. In the other variables measured, the presence of a dental section in the surgery generated a statistically significant difference, with the edema being greater in those who underwent a dental section. This difference was mainly seen in the Ketoprofen group evaluated at 2 postoperative days. The use of any of the 2 drugs is well indicated to alleviate the pain and inflammation of the patient generated by the trauma caused by this type of surgery. Although the group treated with Dexamethasone presented less pain, it was not a significant difference compared to the group with Ketoprofen.

KEY WORDS: dexamethasone, ketoprofen, edema, third Molar, trismus


How to cite this article

COLLAZOS, P. C.; FONSECA. E. D.; PARADA, F. F. & MONTERO, R. S. Comparative study of postoperative anti-inflammatory effectiveness when using intravenous Dexamethasone versus intravenous Ketoprofen prior to extraction of mandibular third molars included. Int. J. Odontostomat., 15(4):1060-1070, 2021.


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