Myoepithelial Carcinoma Ex-pleomorphic Adenoma of Parotid Gland: A Case Report and Immunohistochemical Analysis

2022 • Volume 16 • Issue 3

María Elena Samar Romani; Rodolfo Esteban Avila Uliarte; Alberto Gustavo Corball de Santiago; Ismael Bernardo Fonseca Acosta & Javier Elías Fernández Calderón



Myoepithelial carcinoma is a rare malignant neoplasm of the salivary glands; it may originate de novo or develop into a pre-existing pleomorphic adenoma or myoepithelioma. The histological and immunohistochemical characteristics of a case of myoepithelial carcinoma of the parotid gland originated by the malignant transformation of a previous primary pleomorphic adenoma were investigated in this work. The presence of mitosis, nuclear pleomorphism, necrotic areas, myoepitheliocytes with a p63 labeling greater than 75 % and a proliferative index of 15 % were demonstrated, characteristics that can trigger an adverse outcome. The periodic examination of the patient is essential, which will give a higher probability of cure and survival and to investigate eventual recurrences or metastases.

KEY WORDS: salivary tumors, carcinoma expleomorphic adenoma, myoepithelial carcinoma, immunohistochemistry.


How to cite this article

SAMAR, R. M. E.; AVILA, U. R. E.; CORBALL DE SANTIAGO, A. G.; FONSECA, A. I. B. & FERNÁNDEZ, C. J. E. Myoepithelial carcinoma ex-pleomorphic adenoma of parotid gland: A case report and immunohistochemical analysis. Int. J. Odontostomat., 16(3):377-383, 2022.


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