Use of Injectable Platelet-Rich Fibrin (i-PRF) in Infra Osseous Defects in Non-Surgical Periodontal Therapy. Report of Two Cases

2019 • Volume 13 • Issue 3

Correa, A. J.; Alister, J. P. & Manterola, C.



Second generation platelet concentrates include the use of injectable platelet-rich fibrin (i-PRF), which has generated increasing interest because it is derived from immediate centrifugation of venous blood from the patients themselves. It provides high concentrations of vascular endothelial growth factor, transforming growth factor beta, and platelet-derived growth factor, among other proteins that initiate and coordinate the healing process. Its null cytotoxicity and liquid consistency has opened new research lines in the field of oral surgery and periodontics, as an irrigation substance. The aim of this manuscript was to report the use of i-PRF, as a subgingival irrigator in conventional periodontal treatment of infra osseous defects, with six months follow-up. In both cases, a positive effect of irrigation was confirmed. These findings, open the debate as regards the use of traditional pharmaceutical products (such as chlorhexidine), versus autonomous preparations without adverse effects reported to date.

KEY WORDS: periodontics/therapy, alveolar bone loss, alveolar bone loss/therapy, platelet-rich fibrin i-PRF, therapeutic irrigation, leukocyte- and platelet-rich fibrin.


How to cite this article

CORREA, A. J.; ALISTER, J. P. & MANTEROLA, C. Use of injectable Platelet-Rich Fibrin (i-PRF) in infra osseous defects in non-surgical periodontal therapy. Report of two cases. Int. J. Odontostomat., 13(3):271-274, 2019.


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