Sebaceous Epithelial Myoepithelial Carcinoma of Parotid: Histopathological and Immunohistochemical Analysis

2010 • Volume 4 • Issue 2

Samar María Elena; Avila Rodolfo Esteban; Fonseca Ismael Bernardo & Ferraris Ricardo Virgilio



Epithelial myoepithelial carcinoma (EMC) of the salivary glands is an uncommon, low grade, biphasic neoplasm.We reported a rare case of sebaceous EMC of the parotid gland in a man who had a left parotidectomy because of a tumoral formation apparently encapsulated. For the histopathological and immunohistochemical study the material was stained with H/E, Masson and Dane/Alcian blue trichrome, PAS/H, Toluidine blue, epithelial membrane antigen (EMA), cytokeratins (CK) of low molecular weight, a-smooth muscle actin (a-SMA) and S-100. Histologically, the tumor showed a multinodal pattern with tumoral nests constituted by ducts with a double cell lining: a- luminal cuboidal eosinophilic cells; badluminal clear cells. The inner cells were positively marked with antibodies for EMA and CK. It was observed positive immunoreactivity for a-SMA and S-100 in clear cells. It was observed areas of sebaceous differentiation inside the tumoral mass. Immunohistochemical studies confirmed ductal tumoral and myoepithelial cells presence. Besides, myoepithelial clear cells aided differential diagnosis between sebaceous EMC and sebaceous adenocarcinoma.

KEY WORDS: parotid, epithelial myoepithelial carcinoma, histopathology, immunohistochemistry.


How to cite this article

SAMAR, M. E.; ÁVILA, R. E.; FONSECA, I. B. & FERRARIS, R. V. Sebaceous epithelial myoepithelial carcinoma of parotid: Histopathological and immunohistochemical analysis. Int. J. Odontostomat., 4(2):189-196, 2010.


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