Immunohistochemical Expression of Ki-67 in Central Giant Cell Lesion

2019 • Volume 13 • Issue 2

Adrian Castro Ortega; Daniela Muela Campos; Uriel Soto Barreras & Ronell Bologna-Molina



The central giant cell lesion (CGCL) is a benign osteolytic lesion which in some cases presents an aggressive behavior with recurrence and poor prognosis. Ki67 is a nuclear protein whose general function is the regulation of cell proliferation. This marker is used to identify proliferating cells and as a prognostic tool in the diagnosis of neoplasms. The aim of this study was to quantify the immune expression of Ki-67 in the different cell populations of CGCL and analyze its association with clinical, demographic and radiographic characteristics. The Ki-67 immune expression of 17 cases of LCCG was evaluated in two cell populations: multinucleated giant cells (CGM) and stromal mesenchymal cells (SMC). The statistical analysis was carried out with SAS 9.0 and SPSS version 23.0, with an alpha tax level of P <0.05. The CME showed average immune expression of 9.4 % and the CGM of 0.65 %. No statistically significant relationship was found between the clinical, demographic and radiographic characteristics of the CGCL and the immune expression of Ki-67. The expression of Ki-67 in CME suggests that this population is in constant cellular activity, and that the CGCL are dynamic lesions in a continuous differentiation process.

KEY WORDS: immunoexpression, Ki-67, central giant cell lesion, cell proliferation.


How to cite this article

CASTRO, A. O.; MUELA, D. C.; SOTO, U. B. & BOLOGNAMOLINA, R. Immunohistochemical expression of Ki-67 in central giant cell lesion. Int. J. Odontostomat., 13(2):150-156, 2019.


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