COX-2 Inhibitors in Dental Pain Management

2018 • Volume 12 • Issue 3

Fatima Erendida Del Muro Casas; Karina Gómez Coronado; Nelly Alejandra Rodríguez Guajardo; Manuel Varela-Parga; Jesús Alberto Luengo Ferreira & Juan Carlos Medrano Rodríguez



Pain is a major symptom in many dental procedures. Studies show consistently that pain, including dental pain, is not effectively treated; management of pain is a critical and challenging component in dentistry. Improvement and efficacy on the treatment depends on knowing which treatments are the most effective. Knowing how well an analgesic works and its associated adverse effects is fundamental to clinical decision. The aim of this review is to provide information to the dentistry field on the treatment of dental pain specifically with COX-2 inhibitors providing a useful guide to dentist on controlling pain. Therefore, nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed analgesic agents in surgical outpatients. Major limitations of NSAIDs are their gastrointestinal (GI) adverse events (perforation, ulceration, and bleeding), impairment of hemostatic function, and renal failure (with long-term therapy). A new class of NSAIDs, COX2 selective inhibitors (Coxibs), have been developed with the aim of reducing the GI adverse events of traditional NSAIDs while maintaining their effective anti-inflammatory and analgesic properties.

KEY WORDS: Pharmacology, cox-2 inhibitors, dental pain.


How to cite this article

DEL MURO, C. F. E.; GÓMEZ, C. K.; RODRÍGUEZ, G. N. A.; VARELA-PARGA, M.; LUENGO, F. J. A. & MEDRANO, R. J. C. COX-2 inhibitors in dental pain management. Int. J. Odontostomat., 12(3):225-227, 2018.


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