Antimicrobial Effect of Leukocyte- and Platelet-Rich Fibrin Against Aggregatibacter actinomycetemcomitans Mono-Multiserotypes Model

2021 • Volume 15 • Issue 4

Nicole Lanata-Selingue; Daniel Betancur; Helia Bello-Toledo; Gerardo González-Rocha; Luis Luengo & Gabriela Sánchez-Sanhueza



Leukocyte- and platelet-rich fibrin is a widely used platelet concentrate for periodontal surgery procedures. Many benefits are described regarding its use, such as antimicrobial properties. The objective of this study was to evaluate the antimicrobial effects of the different zones of this platelet concentrated against the most prevalent serotypes of Aggregatibacter actinomycetemcomitans in an in vitro mono-multiserotype model.Three patients who were treated at a School of Dentistry in the city where the researchers reside, were included. Modified direct contact method tests and results were analyzed using multivariate logistic regression analysis. In the modified direct contact method test, a decrease in bacterial count was found at time 1, but at time 2, the count increased for all serotypes and zones of L-PRF. It can be noted that the areas with more cellular content in leukocytes and platelet-rich fibrin are the areas with the most antimicrobial power. This platelet concentrate would have better results with serotype c. At time point 2, it is likely to act as a growth promoter of A. actinomycetemcomitans.

KEY WORDS: Aggregatibacter actinomycetemcomitans, dental implants, infections, platelet-rich fibrin.


How to cite this article

LANATA-SELINGUE, N.; BETANCUR, D.; BELLO-TOLEDO, H.; GONZÁLEZ-ROCHA, G.; LUENGO, L. & SÁNCHEZ-SANHUEZA, G. Antimicrobial effect of leukocyte- and platelet-rich fibrin against an Aggregatibacter actinomycetemcomitans mono-multiserotype model. Int. J. Odontostomat., 15(4):1035-1042, 2021.


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