Platelet concentrates (PC) have emerged as a potential regenerative material, used in isolation or as scaffolding for other graft materials. They are blood extracts, obtained after processing a sample of whole blood, by centrifugation. The first report dates from 1970, with a PC used glue to improve the healing of skin wounds. In 1998, they were used in oral and maxillofacial surgery. Since then, different techniques and a variety of preparations have been developed. These include platelet-rich plasma, fibrin rich in platelets and leukocytes (L-PRF) and plasma rich in growth factors (PRGF). The development of these biomaterials, is due in part to the possibility of altering the concentration of chemical mediators released in a lesion that causes the formation of a clot, which can mature as the phases of the inflammatory process pass and conclude with the complete regeneration of the damaged tissue. The aim of this manuscript was to describe the main intracellular signaling pathways that are activated in the presence of LPRF in oral surgery, and its effects on the regulation of the cell cycle.
KEY WORDS: “Growth Differentiation Factors”[Mesh]; “Receptors, Cytokine”[Mesh]; “Angiogenesis Modulating Agents”[Mesh]; “Periodontics”[Mesh]; “Regenerative Endodontics “[Mesh]; “Platelet-Rich Fibrin”[Mesh]; “Regenerative Medicine”[Mesh].
How to cite this article
CORREA, A. J.; ALISTER, J. P.; OLATE, S. & MANTEROLA, C. L-PRF and cell cycle. A narrative review. Int. J. Odontostomat., 13(4):497-503, 2019.