Comparative Evaluation of Soft Tissue Inflammation in Patients Undergoing Extraction of Third Molars With and Without the Use of PRF

2021 • Volume 15 • Issue 3

Mónica Farías Medina; Sebastián Cádiz Marín; Diego Fonseca Escobar; Fernando Parada Fernández & Sandra Montero Riffo



Third molar extraction is one of the most frequent outpatient procedures in oral surgery, usually requiring osteotomies and odontosection. For this reason, the management of post operative inflammation has been varying in order to obtain better results with the lowest posible risk. The aim was to compare the efficacy of Dexamethasone versus L-PRF in the control of inflammation, pain and trismus in patients without basal pathologies who underwent exodontia of included and semi-included lower third molars. A randomised controlled clinical experimental study was carried out, authorised by the ethics committee of the Universidad Andrés Bello, with code PROPRGFO 54-2019. The simple size was 31 patients, divided into 2 groups, Group A Dexamethasone (15) and Group B PRF (16). Both groups were medicated IV with Cefazolin 1 g and Ketoprofen 100 mg. Exceptionally, group A was given Dexamethasone 4 mg. After the extraction of the third molar, L-PRF was applied to the alveolus of group B patients. The same post-surgical care and medication was indicated for both groups. Each patient was monitored on 4 occasions: Before surgery, immediately after, 72 hours and 7 days after surgery, where facial measurements were recorded according to Neupert’s method. In addition, pain intensity was recorded according to the VAS scale and buccal opening length. There are no statistically significant differences in terms of inflammation between the two groups analysed, nor in L-PRF can be considered as an alternative to classic preoperative medication to reduce inflammation and post operative complications in patients in who use of corticosteroids is contraindicated.

KEY WORDS: oral surgery, platelet-rich fibrin, adrenal cortex hormones.


How to cite this article

FARÍAS, M. M.; CÁDIZ, M. S.; FONSECA, E. D.; PARADA, F. F. & MONTERO, R. S. Comparative evaluation of soft tissue inflammation in patients undergoing extraction of thirdmolars with and without the use of PRF. Int. J. Odontostomat., 15(3):674-680, 2021.


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