Summary
This systematic review purposed to investigate the recurrent intraoral Epithelioid Hemangioendothelioma (EHE) cases into a comprehensive analysis of their demographic, clinical, and immunohistochemical findings. An electronic search was conducted in Embase, PubMed, Scopus, and Web of Science with no restrictions on language or year of publication. All papers included were case reports of recurrent intraoral EHE. The risk of bias was evaluated second to the criteria of the Joanna Briggs Institute (JBI) to systematic review of case reports. This systematic review identified 9 studies from 6 countries, totalizing 10 cases. It was observed a slight predilection for the male gender, with the most of cases reported in gingiva (n = 5/10; 50 %). The main immunohistochemical markers used for diagnostic confirmation of recurrent intraoral EHE were factor VIII and CD34, respectively (n = 2/7; 28.5 % each). No case evaluated resulted in metastasis or evolved into death. Despite the rare occurrence of intraoral Epithelioid Hemangioendothelioma, the rate of recurrence in the oral cavity is relatively high. The initial recognition of the lesion and a careful excision with a good safety margin are essential to minimize the risk of recurrence.
KEY WORDS: Hemangioendothelioma, oral cavity, recurrence.
How to cite this article
LOBO, L. Y.; SANTANA, M. L. A.; SANTOS, C. M.; AMADO-SANTOS, G.; BORGES, P. L.; GOPALSAMY, R. G.; ROQUE- TORRES, G. D.; BRASILEIRO, F. B.; REPEKE, P. C. E.; TAKESHITA, M. W. & TRENTO, C. L. Recurrent epithelioid hemangioendothelioma of the oral cavity: A systematic review. Int. J. Odontostomat., 19(3):347-352, 2025.
