HPV Prevalence on Malignant Lesion Process of the Upper Aerodigestive Tract

Eduardo Serena-Gómez; Ronell Eduardo Bologna-Molina; Alfredo Nevarez-Rascon & Anderson Rocha Buelvas

Summary

Papilovirus or papillomaviruses are considered the most prevalent group of viruses that cause tumors of head and neck associated with infection with human papilloma virus (HPV). According to systematic reviews in Mexico and Colombia, the prevalence of HPV in the process of malignant lesions of the upper aerodigestive tract, can be shown with a clinical prevalence of 35,6% in oropharynx, 23.5% in oral cavity and 24.0% in larynx. This review highlights the genotypes of low-risk HPV (HPV 31, 45, 6 and 11), which induce the appearance of precancerous lesions. It demonstrates the effectiveness of PCR-RFLP method as a starting point for the monitoring of infection and progression to cancer This method can facilitate understanding of its virulence activity and contribute to reduced incidence rates because of the inaccuracies of clinical diagnosis by conventional methods that hinder the early detection of cancer of upper aerodigestive tract.

KEY WORDS: human papillomavirus 16, head and neck neoplasms, tumor virus infections.

How to cite this article

SERENA-GÓMEZ, E.; BOLOGNA-MOLINA, R. E.; NEVAREZ-RASCON, A. & ROCHA B. A. HPV prevalence on malignant lesion process of the upper aerodigestive tract. Int. J. Odontostomat., 5(1):5-12, 2011.