Fluorescence-Guided Bone Resection in Patients With Drug-Associated Osteonecrosis of the Mandible: Scoping Review

2022 • Volume 16 • Issue 2

Joaquín Roco Bazáez; Ariel Pinto Galleguillos & Jessika Dethlefs Canto



Medication-related Osteonecrosis of the jaw (MRONJ) is a serious but low prevalence disease in which the surgical margins of bone resection are clinically determinated by the surgeon based on subjetive parameters. Because of this, fluorescence-guided bone resection has been proposed. The objetive of this study is to describe the current knowledge of fluorescence-guided bone resection in patients with MRONJ. Scoping Review was carried out, searching the databases of PubMed, ScienceDirect and Web of Science, using the boolean operator AND and OR. Inclusion and exclusion criteria were applied. Of 66 articles, 13 were selected that met the eligibility criteriaThe technique of fluorescence with tetracyclines (FT) and autofluorescence (AF) is used, describing a success of 85 to 100 % and 77.3 to 100 % in 1 to 12.9 and 4 to 13.1 months respectively. There was 100 % Clinical-Histopathological correlation for vital and necrotic bone tissue. Fluorescence-guided bone resection is able to clinically discriminate between vital and necrotic bone tissue, allowing the delimitation of surgical margins based on objective and reproducible parameters. In addition, it allows to standardize the surgical procedure.

KEY WORDS: Bone fluorescence, guided resection, MRONJ, medicaments.


How to cite this article

ROCO, B. J.; PINTO, G. A.; DETHLEFS, C. J. Fluorescence-guided bone resection in patients with drug-associated osteonecrosis of the mandible: scoping review. Int. J. Odontostomat., 16(2):321-330, 2022.


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